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Open questions in oxidative stress biology

Dr Sarah Bohndiek (Biological and Soft Systems) and Professor Mete Atatüre and Dr Helena Knowles (Atomic, Mesoscopic and Optical Physics)
This project combines two novel sensing approaches to answer the following open questions in oxidative stress biology:

1.     How do cells adapt their plasma membrane chemistry in response to oxidative stress?

2.     Do these changes help to mediate the common emergence of multidrug resistance in disease, in particular, lung cancer?
The multidisciplinary connections between physical (blue) and chemical (purple) sensing, biochemistry (red), and biomedical applications (green) are required to answer these questions. Collaboration between Prof. Atature (NV sensing) and Dr Bohndiek (Raman sensing) brings together two crucial technologies (blue, purple), in a wet lab environment, which provides a unique opportunity to advance single cell biochemistry. Our goal is to create a system that facilitates simultaneous measurement of physiological parameters with these tools in living cells, to study their impact on drug response and resistance in lung cancer.
SBohndiek Pump Prime Diagram

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